New Arsenal head coach Unai Emery hands debuts to Sokratis Papastathopoulos and Matteo Guendouzi for his first game in charge against Premier League champions Manchester City.
Aaron Ramsey, whose contract expires at the end of the season, is fit to take his place in the Gunners side despite picking up a calf injury while warming up to play Chelsea in pre-season.
Summer arrivals Bernd Leno, Lucas Torreira and Stephan Lichtsteiner could make their competitive debuts from the bench, while Pierre-Emerick Aubameyang is picked to lead the line.
For Man City, Raheem Sterling and Ilkay Gundogan are back in the team for their trip to the Emirates Stadium.
The pair missed the Community Shield last week, Sterling after returning to training late following the World Cup. Petr Cech skippers the side but playmaker David Silva does not feature again after sitting out at Wembley.
Forward Riyad Mahrez makes his league debut for the club following his £60million summer move from Leicester.
Arsenal Starting XI : Cech, Bellerin (C), Papastathopoulos, Mustafi, Maitland-Niles, Guendouzi, Xhaka, Mkhitaryan, Ramsey, Ozil, Aubameyang.
Arsenal Subs: Elneny, Lacazette, Torreira, Lichtsteiner, Holding, Iwobi, Leno.
Manchester City Starting XI : Ederson, Walker, Stones, Laporte, Mendy, Fernandinho (C), Gündogan, Bernardo, Mahrez, Sterling, Agüero.
Manchester City Subs: Bravo, Kompany, De Bruyne, Sane, Otamendi, Jesus, Foden.